Table 1.
Age and sex adjusted baseline demographics and clinical characteristics by RDW percentiles (N = 3,156,863).
Fig 1.
All-cause mortality by RDW and SD-RBC percentiles.
eGFR estimated glomerular filtration rate, RDW red cell distribution width, SD-RBC standard deviation of red blood cell size, WBC white blood cells. Hazard ratios with 95% confidence intervals are reported for: 7 RDW percentile bins (top left), 7 SD-RBC percentile bins (top right), 11 RDW percentile bins (bottom left), and 11 SD-RBC percentile bins (bottom right). The first model (red diamonds) is adjusted for demographics: age, sex, Indigenous status, social assistance and rural status. The second model (blue squares) is adjusted for demographics and all 30 baseline morbidities. The third model (green circles) is adjusted for demographics, morbidities, and baseline hemoglobin, WBC, and eGFR.
Table 2.
Clinical outcomes associated with baseline RDW percentiles.
Fig 2.
All-cause mortality by SD-RBC percentiles, stratified by subgroup.
CAD coronary artery disease, CKD chronic kidney disease, DM diabetes mellitus, eGFR estimates glomerular filtration rate, LR likelihood ratio, MCV mean corpuscular volume, SD-RBC standard deviation of red blood cell size, WBC white blood cells. Hazard ratios with 95% confidence intervals are reported for 7 SD-RBC percentile bins for following subgroups: age (≥65 years vs <65 years), sex, diabetes mellitus, chronic heart failure, coronary artery disease, chronic kidney disease, mean corpuscular volume (above vs below median of 90 fL), and anemia. The model is adjusted for demographics, morbidities, and baseline hemoglobin, WBC, and eGFR.
Fig 3.
Clinical outcomes by RDW and SD-RBC percentiles.
eGFR estimated glomerular filtration rate, ESRD end-stage renal disease (initiation of renal replacement therapy), LTC long-term care, MI myocardial infarction, RDW red cell distribution width, SD-RBC red blood cell standard deviation, TIA transient ischemic attack, WBC white blood counts. Hazard ratios with 95% confidence intervals are reported for 7 RDW (gray squares) and 7 SD-RBC (black squares) percentile bins. The models are adjusted for demographics, morbidities, and baseline hemoglobin, WBC, and eGFR.