Fig 1.
CONSORT flowcharts for experiment 1 and 2.
Table 1.
Overview of experiments and timings of sampling.
Fig 2.
Changes in general self-rated health in response to lipopolysaccharide (LPS) and placebo.
In Experiment 1, measures were made prior to, 1.5h, and 4.5h after an LPS injection of 0.8ng/kg body weight (a solid red line with filled circles) or placebo (saline, a blue solid line with filed circles). In Experiment 2, measures were made 1.5h post injection with an LPS injection of 0.6ng/kg body weight (non-filled red/marron squares) and placebo (non-filled navy blue squares) only. Means and standard error are depicted. Note that the y-scale is reversed, 1 = very good, 5 = very poor.
Table 2.
Estimates of effects on general and current health by experimental immune activation with LPS versus placebo, and time.
Fig 3.
Changes in current self-rated health in response to lipopolysaccharide (LPS) and placebo.
In Experiment 1, measures were made on several time points prior and post to a LPS injection of 0.8ng/kg body weight (a solid red line with filled circles) or placebo (saline, a blue solid line with filled circles). In Experiment 2 injection with an LPS injection of 0.6ng/kg body weight (a red/marron dashed line and non-filled squares) and placebo (a navy blue dashed line with un-filled squares). Means and standard errors are depicted. 1 = very poor health, 7 = excellent health.
Fig 4.
Path analysis for current health.
The model describes the relationship between experimental immune activation with LPS, increase in inflammation, increase in perceived sickness behaviour and a poorer self-rated current health status, between baseline and peak inflammatory activity 1.5h after injection with LPS/placebo (n = 46). Direct paths are adjusted for the other variables presented in the model and are depicted with continuous lines, significant paths are depicted with bold lines. There was a significant indirect path connecting LPS with change in current SRH via change in inflammation and change in sickness behaviour, depicted with a bold dashed line.