Fig 1.
Flow chart of the study population.
* The observation period ranges from 3 months before initiation of first long-term (≥ 3 months) oral glucocorticoid treatment to 7 months after the date of last glucocorticoid prescription (cessation).
Fig 2.
Observation period and defined risk periods for an individual person receiving oral glucocorticoid treatment who stops treatment before end of follow up.
Table 1.
Characteristics of 286,680 oral glucocorticoid users according to sex, age, glucocorticoid type, dose, and morbidity as of the date of cessation.
Table 2.
Incidence rates per 1000 person-years with 95% confidence intervals (CI) (n = 286,680).
Fig 3.
The 2-week prevalence (per 1000 persons) of clinical indicators of adrenal insufficiency and the negative outcome during the period of 12 month before the last glucocorticoid prescription to 7 months after this prescription.
(a) All clinical indicators. (b) Gastrointestinal symptoms. (c) Hypotension. (d) Cardiovascular collapse. (e) Hyponatremia. (f) Hypoglycemia. (g) Syncope. (h) Negative outcome.
Table 3.
Incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for events by risk period.
Table 4.
Risk factors for clinical indicators of adrenal insufficiency.