Fig 1.
The effective record contribution of the 14,778 genotyped bulls.
Fig 2.
Distribution by animal age (in years) of the total number of tests carried out (primary axis; filled) and the number of positive results returned (secondary axis; no fill) during bovine tuberculosis-breakdowns.
Table 1.
Associations between the life stage of the animal on the odds ratio of a positive bTB diagnosis (95% CI in parentheses) relative to the referent life stage of a calf.
Fig 3.
Distribution of the mean prevalence of bovine tuberculosis in the progeny of 1,262 sires that produced at least 50 progeny in 10 bovine tuberculosis-breakdowns.
Fig 4.
Distribution of the mean sire EBV (primary axis; line) and individual sire EBV (secondary axis; diamond) per year of birth for a) 243 beef AI sires and b) 799 dairy AI sires that had ≥ 20 progeny with a bovine tuberculosis phenotype in at least 2 herds.
Fig 5.
Manhattan plot showing–log10 (P-values) of association between each single nucleotide polymorphism effect and the weighted deregressed EBV for bovine tuberculosis infection in the multi-breed analysis of 7,346 bulls; red and blue lines represent genome-wide and suggestive thresholds, respectively.
Table 2.
Chromosome (BTA), position, P-value, the favorable allele, the frequency of the favorable allele, substitution effect of the favorable allele, annotation, and gene for the 38 single nucleotide polymorphisms associated with bovine tuberculosis infection (P < 1 x 10−6).
Table 3.
Chromosome (BTA), start position, end position, number of suggestive single nucleotide polymorphisms (SNPs), and the genes identified in quantitative trait loci that had at least six suggestive single nucleotide polymorphisms (P < 1 x 10−5) associated with bovine tuberculosis infection.
Table 4.
Bovine biological pathways associated with bovine tuberculosis infection.
Table 5.
Top ten biological pathways associated with bovine tuberculosis infection predicted by orthology from humans.
Fig 6.
Manhattan plot showing–log10 (P-values) of association between each single nucleotide polymorphism effect and the weighted deregressed EBV for bovine tuberculosis infection in the within-breed analyses for (a) the 2,039 purebred Charolais bulls, (b) the 1,964 purebred Limousin bulls, and (c) the 1,502 purebred Holstein-Friesian bulls; red and blue lines represent genome-wide and suggestive thresholds, respectively.