Fig 1.
The two fibril types shown by western blotting analysis.
Western blots subjected to an antiserum directed against the C-terminal part of transthyretin (amino acids 50–127) are shown for patient IVA and IVB, as well as positive controls for both fibril types. Patient IVA is seen to have a clear band below the band corresponding to the full-length monomeric transthyretin, while patient IVB does not.
Table 1.
Amyloid fibril composition within the families.
Fig 2.
Scatterplot of amyloid fibril type and age at onset.
Type A fibrils contain transthyretin fragments. Type B fibrils contain only full-length transthyretin. Bars represent median and 95% confidence interval.