Table 1.
ABC36 cognitive test scores and imprint methylation levels in blood DNA.
Table 2.
ABC21 cognitive test scores and imprint methylation levels in blood DNA.
Fig 1.
Brain and blood methylation comparison.
DNA methylation in the imprints H19ICR, IGF2, IG-DMR, KvDMR, MEST1, NESPAS, PEG3, SNRPN and ZAC1 in blood from ABC36 (n = 485) and five selected regions from four brains sampled post-mortem (AH: Anterior Hippocampus. BG: Basal ganglia. PH: Posterior Hippocampus. PWM: Periventricular white matter. TH: Thalamus). The individual methylation values for each brain sample are shown with cases (individuals with evidence of Alzheimer’s Disease) represented by open circles and controls (no apparent neurodegeneration beyond that expected for age) by closed circles. The population distribution of methylation levels in blood are shown on the same methylation scale.
Table 3.
DNA methylation in imprints and measures of childhood and adult cognitive ability in ABC36.
Fig 2.
SNRPN and MEST1 methylation in ABC cohorts.
Regression coefficients with 95% CIs from regressions between SNRPN and MEST1 methylation in ABC36, ABC21 and the combined cohort and childhood cognitive ability measured at age 11 using the Moray House Test (MHT). All regressions were adjusted for sex, adult socioeconomic circumstance (index of multiple deprivation decile), plate and the combined cohort was additionally adjusted for cohort.