Fig 1.
Time schedule of low-pressure exposure (upper panel) and control condition (lower panel). Barometric pressure was lowered from 1013 hPa to 973 hPa.
Fig 2.
Photomicrographs of the superior vestibular nucleus (SuVe) (A: left and B: right) and the lateral vestibular nucleus (LVe) (C: left and D: right) in male mice 2 h after low-pressure exposure (A1, B1, C1, and D1) and under control conditions (A2, B2, C2, and D2). Arrowheads indicate c-Fos-positive cells. The histological sections are shown as gray squares in the schematic drawing of the medulla oblongata (upper panel).
Fig 3.
Photomicrographs of the spinal vestibular nucleus (SpVe) and medial vestibular nucleus (MVe) (A: left and B: right) in male mice 2 h after low-pressure exposure (A1 and B1) and under control conditions (A2 and B2). Arrowheads indicate c-Fos-positive cells. The histological sections are shown as gray squares in the schematic drawing of the medulla oblongata (upper panel).
Fig 4.
Number of c-Fos-positive cells in each vestibular nucleus.
Quantification of c-Fos-positive cells in the (a) superior vestibular nucleus (SuVe), (b) lateral vestibular nucleus (LVe), (c) medial vestibular nucleus (MVe), (d) spinal vestibular nucleus (SpVe), in female (n = 8 per group) and male (n = 9 per group) mice 2 h after lowering barometric pressure stimulation (LP: 973 hPa) or under control conditions (Con: 1013 hPa). Each bar represents the mean + standard error; **, p < 0.01 (two-way ANOVA followed by Tukey-Kramer test).
Table 1.
Total activity scores for female and male mice.
Behaviors of each mouse during the 30 min before and 30 min after the beginning of LP stimulation were recorded (LP exposure). In control animals, the total activity score was calculated over a period of 60 min without LP stimulation (Control condition). Each number represents the mean ± standard error of the activity score.