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Fig 1.

Molecular structure of amitriptyline hydrochloride (AMH).

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Fig 1 Expand

Fig 2.

Synthesis route of the biodegradable cationic gemini surfactants (16-E2-16).

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Fig 2 Expand

Table 1.

The origin and purity of the molecules utilized in the current work.

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Table 1 Expand

Fig 3.

Surface tension (γ) versus concentration (m) isotherms for pure amphiphiles ((A) AMT and (B) 16-E2-16) in different media at 298.15 K.

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Fig 3 Expand

Fig 4.

Surface tension (γ) with concentration (m) isotherms for AMH-16-E2-16 mixture in different ratio (different mole fraction of 16-E2-16 (α1)): (A) aqueous solution, (B) 50 mmol∙kg-1 NaCl, (C) 500 mmol∙kg-1 NH2CONH2 solution and (D) 1000 mmol∙kg-1 NH2CONH2 solution at 298.15 K.

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Fig 4 Expand

Table 2.

Physicochemical parameters for AMH-16-E2-16 mixtures in different media at temperature T = 298.15 K and pressure p = 0.1 MPaa.

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Table 2 Expand

Fig 5.

Variation of cmc/cmcid of AMH-16-E2-16 mixture versus mole fraction (α1) of 16-E2-16.

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Fig 5 Expand

Table 3.

Surface parameters for AMH-16-E2-16 mixtures in different media at temperature T = 298.15 K and pressure p = 0.1 MPaa.

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Table 3 Expand

Fig 6.

Variations of ΔGom versus mole fraction of 16-E2-16 (α1) in AMH-16-E2-16 mixed systems at temperature T = 298.15 K in different media at 298.15 K.

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Fig 6 Expand

Table 4.

Thermodynamic parameters for AMH-16-E2-16 mixtures in different media at temperature T = 298.15 K and pressure p = 0.1 MPaa.

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Table 4 Expand

Table 5.

Packing parameter for mixed AMH-16-E2-16 systems in different media at temperature T = 298.15 K and pressure p = 0.1 MPaa.

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Table 5 Expand

Fig 7.

Fluorescence spectra of 10−6 M pyrene of (A) pure 16-E2-16, and (B) 16-E2-16 (0.4) + AMH (0.6) mixture at different quencher concentrations in aqueous micellar solution.

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Fig 7 Expand

Table 6.

Aggregation number (Nagg) and other related parameters for AMH-16-E2-16 mixtures in different media at temperature T = 298.15 K and pressure p = 0.1 MPaa.

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Table 6 Expand

Fig 8.

FTIR spectra of (A) 16-E2-16 in absence and presence of AMH in equal ratio and (B) AMH in absence and presence of 16-E2-16 in equal ratio.

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Fig 8 Expand