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Table 1.

Psychological domains investigated in long term analyses.

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Table 1 Expand

Table 2.

Reported dosage by substance.

Note that units of measurement vary across substances.

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Table 2 Expand

Fig 1.

Daily ratings for each variable at Baseline, Dose Day (dosing day), Dose+1 (the day after dosing), and Dose+2 (2 days after dosing).

Error bars show 95% confidence intervals. * indicates a significant difference from baseline (adjusted p < .05).

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Fig 1 Expand

Table 3.

Mean (SD) and contrast tests for daily ratings.

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Table 3 Expand

Fig 2.

Baseline and post study scores.

These panels show distributions and summary statistics for each long term measure at baseline and post study. Boxplots show median and inter quartile ranges for each variable. Violin plots show the distribution of responses. The green line plots the difference between means from baseline to post study. * indicates a significant difference from baseline to post study (adjusted p < .05).

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Fig 2 Expand

Table 4.

Long term battery scores.

This table shows baseline and post study means and standard deviations for each measure. Also shown are test statistics for the three critical analyses: the main effect of Time, and interactions of Time x Experience and Time x Dose. p-values are adjusted using Holm-Bonferroni correction for three comparisons. R2C estimates the variance explained by each model. A complete model summary table is included as Table D in S1 File.

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Table 4 Expand

Table 5.

Participant comments demonstrating experiences of absorption, intense emotions and unease.

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Table 5 Expand

Table 6.

Expectation items that were rated for each subscale; weighted expectation scores (positive scores indicate an expectation that this subscale would increase, negative scores indicate an expectation that this subscale would decrease); one-sample t-test results comparing weighted expectations score to 0; rank order of expectation effects (based on weighted expectation scores); rank order of effects found in Study One (based on t value for main effect of Time in Study One).

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Table 6 Expand