Fig 1.
FT-IR absorption spectra for TP (1), β-CD (2), TP-β-CD inclusion complex (3) and calculated IR absorption TP spectrum (B3LYP/6-31G) (4).
Fig 2.
Raman spectra for TP (1), β-CD (2) and TP-β-CD inclusion complex (3).
Fig 3.
DSC thermograms of TP (1), β-CD (2) and TP-β-CD inclusion complex (3).
Fig 4.
The conformation of the most stable complex of TP and β-CD.
Table 1.
Relative energies of TP-β-CD complexes in respect to the angle of rotation of guest molecule rotated in the cavity.
Fig 5.
The chromatogram of TP in the presence its of the main impurity—tebipenem.
Table 2.
Validation parameters for HPLC-DAD method.
Fig 6.
Phase-solubility diagram of TP inclusion complex in water.
Fig 7.
Dissolution profiles for TP (1), TP-β-CD physical mixture (2) and TP-β-CD inclusion complex (3) in artificial gastric juice at pH 1.2.
Fig 8.
Dissolution profiles for TP (1), TP-β-CD physical mixture (2) and TP-β-CD inclusion complex (3) in phosphate buffer at pH 7.2.
Fig 9.
The semi-log plots of c = f(t) for degradation of TP and TP-β-CD inclusion complex studies at an increased relative air humidity (RH ~ 76%, T = 303–343 K) (A) and in dry air (RH = 0%, T = 333–363 K) (B).
Table 3.
Kinetic and thermodynamic parameters of the degradation of TP in free form and in complex with β-CD.
Table 4.
The permeability values and efflux ratios of pure TP and TP-β-CD inclusion complex.
Table 5.
Values of MIC (mg L-1) of TP and TP-β-CD inclusion complex against selected Gram-positive and Gram-negative bacteria.