Table 1.
Ototoxicity classification systems.
Table 2.
Baseline characteristics of included patients.
Table 3.
Grade distribution (%) based on the last available audiogram according to different CTCAEv4.03, Muenster, SIOP, Brock and Chang classification systems.
Fig 1.
Prevalence of deleterious hearing loss (A) based on CTCAEv4.03 ≥grade 2, Muenster ≥grade 2b, SIOP ≥grade 2, Brock ≥grade 2 and Chang ≥grade 2a, and ototoxicity grade distribution (B) according to the last available audiogram.
Table 4.
The prevalence of deleterious hearing loss at stop treatment, 1 year after stop and 10 years after stop treatment.
Table 5.
Concordance among different ototoxicity criteria.
Fig 2.
Progression of hearing loss based on Muenster grade.
The time after start cisplatin treatment in 654 patients is depicted on the x-axis and the hearing loss grade is depicted on the y-axis. The dots represent the mean and the whiskers represent the standard error of the mean ototoxicity grade. The dotted horizontal line depicts the cut-off for hearing loss yes/no.
Fig 3.
Progression of hearing loss based on Brock grade.
The time after start cisplatin treatment in 654 patients is depicted on the x-axis and the hearing loss grade is depicted on the y-axis. The dots represent the mean and the whiskers represent the standard error of the mean ototoxicity grade. The dotted horizontal line depicts the cut-off for hearing loss yes/no.
Fig 4.
Progression of hearing loss based on SIOP grade.
The time after start cisplatin treatment in 654 patients is depicted on the x-axis and the hearing loss grade is depicted on the y-axis. The dots represent the mean and the whiskers represent the standard error of the mean ototoxicity grade. The dotted horizontal line depicts the cut-off for hearing loss yes/no.
Fig 5.
Progression of hearing loss based on Chang grade.
The time after start cisplatin treatment in 654 patients is depicted on the x-axis and the hearing loss grade is depicted on the y-axis. The dots represent the mean and the whiskers represent the standard error of the mean ototoxicity grade. The dotted horizontal line depicts the cut-off for hearing loss yes/no.