Fig 1.
Evoked excitatory AMPA/KA post-synaptic currents (EPSCs) in CA1 pyramidal cells.
A. EPSCs recorded in the presence of Picrotoxin (20 μM) at -80 mV from control and stimulated animals. D. Mean AMPA/KA current amplitudes evoked at -80 mV. C. IV relationships for AMPA/KA currents. C. EPSCs in response to a 20 Hz train of stimuli. D. P1/Pn relationships.
Fig 2.
Evoked excitatory NMDA post-synaptic currents (EPSCs) in CA1 pyramidal cells.
A. EPSCs recorded in the presence of picrotoxin (20 μM) and DNQX (10 μM) at +50 mV from control and stimulated animals. B. Mean NMDA current amplitudes evoked at +50 mV. C. IV relationships for DNQX-sensitive NMDA currents.
Fig 3.
Spontaneous inhibitory post-synaptic currents (sIPSCs) in CA1 pyramidal cells.
A. sIPSCs recorded in the presence of DNQX (10 μM) at -80 mV, from control and stimulated animals. B. Mean frequency of IPSCs from controls and stimulated animals. Ci. Mean current amplitudes and, Cii, Amplitude histograms of spontaneous currents from control and stimulated animals (error bars were omitted for clarity). D. Mean half-widths of recorded IPSCs from control and stimulated animals. *p<0.05.
Fig 4.
Spontaneous miniature inhibitory post-synaptic currents (mIPSCs) in CA1 pyramidal cells.
A. Current traces recorded in the presence of DNQX (10 μM) and TTX (1 μM) at -80 mV, from control and stimulated animals. B. Mean frequency of mIPSCs from controls and stimulated animals. Ci. Mean current amplitudes and Cii, amplitude histograms of spontaneous currents from control and stimulated animals (error bars were omitted for clarity). D. Mean half-widths. E. Mean fast decay time constants. F. Mean slow decay time constants. *p<0.05, ***p<0.001.