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Fig 1.

Literature search and study selection.

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Fig 2.

Bubble chart displaying studies included in review by study year, geographic region, and type of economic evaluation.

Balloon size depicts the number of citations through Google Scholar.

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Fig 3.

Data sources used by LD cost-effectiveness analyses and cost analyses.

* New Jersey Blue Cross—Blue Shield; Diversified Pharmaceutical Services; Delmarva Health Plan; Swedish Social Insurance; German DAK; IMS Health LifeLink Health Plan Claims; ** CDC LD Incidence Reports, Epidemiologic Reports, Lyme Disease Vaccine Study Group; *** Scottish Health Service, Departments of Economy and Information Technology.

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Fig 3 Expand

Table 1.

Economic evaluation study characteristics.

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Table 2.

Primary study characteristics and conclusions of cost-effectiveness analyses.

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Table 2 Expand

Table 3.

Summary of standardized ICER for vaccination programs in the United States.

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Table 3 Expand

Table 4.

Primary study characteristics and conclusions of cost analyses.

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