Fig 1.
Correlation of nationwide fluoroquinolone use and resistance rates to fluoroquinolone of Escherichia coli (FQN-R-ECO), isolated from general hospitals from 2002 to 2013.
(A) Correlation of total fluoroquinolone use and rates of FQN-R-ECO (Correlation coefficient r = 0.82, P = 0.0012); (B) Correlation of ciprofloxacin use and rates of FQN-R-ECO (Correlation coefficient r = 0.90, P<0.0001).
Fig 2.
Correlation of nationwide cephalosporin/fluoroquinolone use and resistance rate to cefotaxime of Escherichia coli (CTX-R-ECO), isolated from general hospitals from 2002 to 2013.
(A) Correlation of total third-generation cephalosporin use and rate of CTX-R-ECO (Correlation coefficient r = 0.96, P<0.0001); (B) Correlation of cefotaxime use and rate of CTX-R-ECO (Correlation coefficient r = 0.94, P<0.0001); (C) Correlation of total third- plus fourth-generation cephalosporin use and rate of CTX-R-ECO (Correlation coefficient r = 0.99, P<0.0001).
Fig 3.
Correlation of nationwide cephamycin use and resistance rate to cefoxitin of Escherichia coli (FQX-R-ECO), isolated from general hospitals from 2002 to 2013.
(A) Correlation of total cephamycin use and rate of FOX-R-ECO (Correlation coefficient r = -0.61, P = 0.0600); (B) Correlation of total cephamycin use and rate of FOX-R-ECO at two-year intervals (Correlation coefficient r = 0.64, P = 0.0256); (C) Correlation of cefoxitin use and rate of FOX-R-ECO (Correlation coefficient r = 0.73, P = 0.0158).