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Fig 1.

Several data source scenarios for generalization from the trial (S = 1) to the target population (P = 1).

(a) the trial sample and a full population dataset; (b) the trial sample and a dataset (S = 2) that is representative of the population; (c) the trial sample and some summary statistics about the population.

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Fig 1 Expand

Table 1.

Key assumptions.

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Table 1 Expand

Table 2.

Implementation instructions.

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Table 2 Expand

Table 3.

Weighting procedures for different target population data scenarios.

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Table 3 Expand

Table 4.

Illustration.

Data availability.

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Table 5.

Illustration.

Covariate balance within the trial sample.

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Table 6.

Illustration.

Covariate distribution in the trial sample and target population.

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Table 7.

Illustration.

Excerpt from effect modification modela fit to trial data.

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Table 7 Expand

Fig 2.

Illustration.

Visualization of effect modification model.

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Fig 2 Expand

Table 8.

Illustration.

Covariate balance between two trial arms and target population after weighting.

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Table 8 Expand

Table 9.

Illustration.

Excerpt from effect modification model fit to trial data that have been weighted to the target population.

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Fig 3.

Illustration.

Results from both methods.

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Fig 3 Expand