Table 1.
Demographics of the migraine group including whether individuals were aura or non-aura sufferers (MA/MO), age at time of testing, age of first migraine onset, number of attacks per year, number of days post-migraine at time of testing, MIDAS grade and average pain rating of their migraine attacks.
Fig 1.
Example magnetic resonance spectroscopy spectrum and stimulus sequence for the binocular rivalry task.
(a) An example spectrum measured from the visual cortex of a migraine participant. Frequency and phase correction are performed on the pre-aligned raw spectrum (red) using Gannet to generate a post-align spectrum (blue). Gannet then generates best fit curves of the (b) Glx (c) GABA peaks on the post-align spectrum (blue). Glx and GABA concentrations are defined as the area under the fitted curves (red). Inset figure illustrates the voxel placement at the occipital cortex. (d) Stimulus sequence used to assess binocular rivalry. A green grating oriented at 135° was shown to the left eye while a red grating oriented at 45° was shown to the right eye throughout each 90s test block. Observers perceived switches between the red and green grating within the 90s test blocks.
Fig 2.
Group averaged GABA and Glx levels.
Individual measures (small symbols, jittered along the x-axis) and group averages (large symbols; error bars represent 95% confidence intervals) of occipital (a) GABA+/water, (b) Edited-Glx/water, and (c) GABA/Glx ratio, obtained from the visual cortex of controls (filled) and migraineurs (unfilled) Migraine with aura are represented by squares, and migraine without aura by triangles.
Fig 3.
Group averaged rivalry percept duration.
Individual measures (small symbols, jittered along the x-axis) and group averages (large symbols; error bars represent 95% confidence intervals) of median percept duration (a) in controls (filled) and migraineurs (unfilled). Migraine with aura are represented by squares, and migraine without aura by triangles.
Fig 4.
Relationship between median percept duration for the binocular rivalry task and the GABA+/water in visual cortex.
Data is shown for each group separately but pooled to determine the correlation. Migraine with aura are represented by squares, and migraine without aura by triangles. Controls are filled circles.