Fig 1.
Workflow of shotgun proteomics analysis.
Fig 2.
Venn diagram identifying the overlapped and unique proteins of dog and human saliva.
Fig 3.
Representative SDS-PAGE of 50 μg protein from dog saliva pool and human saliva pool.
Fig 4.
Comparison of functional characteristic of proteins found only in dogs and human.
*: Dominant functions found in human. **: Dominant functions found only in dogs.
Table 1.
Unique proteins from dominant functions found only in dog or human.
Table 2.
Expression level of proteins in dog compared to human.
Fig 5.
Immunoblotting analysis of salivary proteins (BIRC2, amylase and carbonic anhydrase 6) was performed in dog and human samples.
Fig 6.
Protein-drug interaction network of proteins dominate in human and dogs.
Interaction network was predicted by STITCH version 5.0 (http://stitch.embl.de). Proteins network related to anticancer agents. Bold box: proteins related to the drugs, Dashed box: proteins non-related to the drugs.
Fig 7.
Protein-drug interaction network of proteins dominate in human and dogs.
Interaction network was predicted by STITCH version 5.0 (http://stitch.embl.de). Proteins network related to anti-inflammatory agents. Bold box: proteins related to the drugs, Dashed box: proteins non-related to the drugs.
Fig 8.
Protein-drug interaction network of proteins dominate in human and dogs.
Interaction network was predicted by STITCH version 5.0 (http://stitch.embl.de). Proteins network related to antimicrobial agents. Bold box: proteins related to the drugs, Dashed box: proteins non-related to the drugs.