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Fig 1.

PRISMA flow diagram detailing process of study selection for the meta-analysis.

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Table 1.

Summary characteristics of the studies included in the analysis.

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Fig 2.

Summary assessment of risk of bias of the included studies.

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Fig 3.

Forest plot analysis of body weight (BW) in participants treated with metformin compared with placebo.

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Fig 4.

Summary data of outcome parameters.

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Fig 5.

Forest plot analysis of total cholesterol in participants treated with metformin compared with placebo.

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Fig 6.

Forest plot analysis of LDL cholesterol in participants treated with metformin compared with placebo.

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