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Fig 1.

Prisma flow chart of database search.

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Table 1.

Bias risk in selected studies.

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Table 2.

Summary of selected studies.

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Table 3.

Likelihood ratios for each presentation where indicted in selected studies.

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Fig 2.

Forest plots with pooled diagnostic odds ratio (95% confidence interval) and weights calculated using a random effects model for haemoptysis in the diagnosis of lung cancer.

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Fig 3.

Forest plots with pooled diagnostic odds ratio (95% confidence interval) and weights calculated using a random effects model for Dyspnoea in the diagnosis of lung cancer.

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Fig 4.

Forest plots with pooled diagnostic odds ratio (95% confidence interval) and weights calculated using a random effects model for Cough in the diagnosis of lung cancer.

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Fig 5.

Forest plots with pooled diagnostic odds ratio (95% confidence interval) and weights calculated using a random effects model for Chest Pain in the diagnosis of lung cancer.

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Fig 6.

Summary Receiver Operator Curve for Haemoptysis as a diagnostic symptom in lung cancer.

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Fig 7.

Summary Receiver Operator Curve for Dyspnoea as a diagnostic symptom in lung cancer.

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Fig 8.

Summary Receiver Operator Curve for Cough as a diagnostic symptom in lung cancer.

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Fig 9.

Summary Receiver Operator Curve for Chest pain as a diagnostic symptom in lung cancer.

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Table 4.

Positive Likelihood Ratios (LR) for symptoms in Lung Cancer patients prior to diagnosis.

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Table 5.

Clinical case analysis using prior risk assessment and Bayesian incorporation of clinical symptoms to determine posterior risk.

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