Fig 1.
Consort diagram of the study population.
Table 1.
Baseline characteristics of the study population.
Table 2.
Biomarkers at baseline, prior to cycle 3 and at 2 months’ follow up, for all patients and by treatment arm.
Fig 2.
Heat map of biomarker correlations at baseline.
TF = Tissue factor; EV-TF = Tissue factor associated with extracellular vesicles; PPL = Procoagulant phospholipids; TG = Thrombin generation; ttPeak = Time to peak; ETP = Endogenous thrombin potential. Please note, TG-ttPeak and PPL are inversely correlated to procoagulant activity, whereas all other biomarkers are positively correlated. * P <0.05; ** P <0.001.
Table 3.
Coagulation biomarkers at baseline vs VTE incidence by treatment arm.
Fig 3.
Kaplan-Meier curve of overall survival based on TG-Peak at baseline (tertiles), for all patients and by disease extent.
Table 4.
Mortality ratios vs biomarker levels at baseline, for all patients and by disease stage.
Fig 4.
Kaplan-Meier curve of the predictive values of baseline EV-TF (cut-off at the 75th percentile) on the effect of LMWH on overall survival, for all patients and by disease extent.