Table 1.
Healthy control group and local T1D cohort characteristics and MMTT results.
Fig 1.
Secretion profiles of healthy cohort (n = 13) following a standard MMTT.
Values measured at 11 time points over a 240-minute collection period. a. C-peptide and glucose secretion b. Proinsulin and glucose secretion c. Proinsulin and C-peptide secretion.
Fig 2.
Change in CP (median with IQR) during MMTT, stratified by non-fasting PI (T1D) versus controls.
Change in CP in the healthy cohort was greater than either T1D cohort. Change in CP in the T1D group with a non-fasting PI below 6 pmol/L was 2 times greater than those with a non-fasting PI above 6 pmol/L, suggesting differences in nutrient stimulated beta cell response. Data passed the Kruskal-Wallis test (p <0.0001) with Dunn’s post-test used to compare groups. *P-value ≤ 0.05.
Table 2.
Local T1D cohort MMTT data: 3 Subjects with measurable proinsulin.
Table 3.
Non-fasting and MMTT results from T1D cohort stratified by non-fasting PI.