Table 1.
Anthropometric and laboratory data between patients with subtotal gastrectomy (Billroth II anastomosis and Roux-en Y gastrojejunal anastomosis) and patients without gastric surgery with a median follow-up of 8.25 years.
Table 2.
Anthropometric and laboratory data between patients with subtotal gastrectomy and patients without gastric surgery with a median follow-up of 8.25 years.
Table 3.
Anthropometric and laboratory data between patients (subtotal gastrectomy) and controls with fecal microbiome with a median follow-up of 8.25 years.
Fig 1.
Richness and diversity of gut microbiota in the BII, RYGJ, and control groups.
Chao1 and ACE indexes showed no significant difference in bacterial richness among B-II group and control group (P > 0.05). Chao1 and ACE indices showed significant differences in bacterial richness among RYGJ group and control group (P < 0.05). RYGJ group showed much higher bacterial diversity, as estimated by the Shannon diversity index (SI), in comparison with control group (P < 0.05). There was no significant difference in bacterial diversity among the BII and control groups (P > 0.05). The boxes (containing 50% of all values) show the median (horizontal line across the middle of the box) and the interquartile range, whereas the whiskers represent the 25th and the 75th percentiles. ACE, abundance‐based coverage estimators; C, control; B-II, subtotal gastrectomy with Billroth II anastomosis; RYGJ, subtotal gastrectomy with Roux-en-Y gastrojejunal anastomosis.
Fig 2.
Principal component analysis of bacterial genera abundance.
Principal component analysis of bacterial genera abundance showed a clear separation between control and BII or RYGJ groups. C, control; BII, subtotal gastrectomy with Billroth II anastomosis; RYGJ, subtotal gastrectomy with Roux-en-Y gastrojejunal anastomosis.
Fig 3.
Relative abundances of classes across three groups.
C, control; B-II, subtotal gastrectomy with Billroth II anastomosis; RYGJ, subtotal gastrectomy with Roux-en-Y gastrojejunal anastomosis.
Fig 4.
Known genera abundance reported by LEfSe in the bacterial community.
Fig 4A. Known genera abundance reported by LEfSe in the bacterial community between B-II and control group. B-II, subtotal gastrectomy with Billroth II anastomosis.1This Prevotella genus is affiliated with Prevotellaceae. 2This Prevotella genus is affiliated with Paraprevotellaceae, a recommended family (based on the Greengenes database). 3This Clostridium genus is affiliated with Ruminococcaceae. 4This Clostridium genus is affiliated with Peptostreptococcaceae, a recommended family (based on the Greengenes database) Fig 4B. Known genera abundance reported by LEfSe in the bacterial community between RYGJ and control group. RYGJ, Roux-en-Y gastrojejuno anastomosis. 1This Ruminococcus genus is affiliated with Ruminococcaceae. 2This Ruminococcus genus is affiliated with Lachnospiraceae, a recommended family (based on the Greengenes database). 3 This Clostridium genus is affiliated with Lachnospiraceae. 4This Clostridium genus is affiliated with Ruminococcaceae. 5This Clostridium genus is affiliated with Peptostreptococcaceae, a recommended family (based on the Greengenes database).