Fig 1.
Spectral-domain optical coherence tomography imaging and parameters’ measurements.
The infrared image in (A) shows 24 radial B-scans centered on the ONH (dark green radial lines) acquired relative to the orientation of the FoBMO center axis (green arrow connecting the fovea and the BMO center, -9.5° in this subject). In (B), one horizontal radial B scan shows MRW measurements. MRW (cyan arrow) is the minimum distance between BMO (red dots) and ILM (delineated in red). Each B scan yield 2 BMO points and 2 MRW measurements, in this example a nasal (N) and a temporal (T) measurement. The 3D coordinates of each of the 48 BMO points are used to fit a spline which derives a closed curve representing the BMO area (1.81 mm in this disc). In (C) the 3.5 mm diameter circular scan (light green circle) centered on the ONH was used for RNFLT measurements. (D) Is the corresponding circular B-scan showing the ILM (red) and RNFL (cyan) delineations. MRW and RNFLT measurements were averaged and analyzed globally and in 6 sectors: ST(superotemporal), SN (superonasal), IT (inferotemporal), IN (inferonasal), T (temporal), and N (nasal), in relation to the FoBMO center axis.
Fig 2.
Smoothed histogram showing the distribution of Bruch’s membrane opening (BMO) areas for each race.
ED: European Descent; AD: African Descent; MD: Mixed Descent.
Fig 3.
Graphs showing (A) minimum rim width (MRW) and (B) peripapillary retinal nerve fiber layer thickness (RNFLT) profiles for each race. ED: European Descent; AD: African Descent; MD: Mixed Descent. T: temporal; S: superior; N: nasal; I: inferior.
Table 1.
Clinical characteristics of study subjects.
Table 2.
Comparison of global and sectorial minimum rim width (MRW) measurements by race.
Table 3.
Comparison of global and sectorial retinal nerve fiber layer thickness (RNFLT) measurements by race.
Fig 4.
(A) Scatterplots showing the relationship between global minimum rim width (MRW) and age (left) and global peripapillary retinal nerve fiber layer thickness (RNFLT) and age (right), by racial group. Lines represent the coefficients of multivariable regression, adjusted for Bruch’s membrane opening area. (B) Scatterplots showing the relationship between global minimum rim width (MRW) and Bruch’s membrane opening (BMO) area (left) and global peripapillary retinal nerve fiber layer thickness (RNFLT) and BMO area (right) by racial group. Lines represent the coefficients of multivariable regression, adjusted for age. ED: European Descent; AD: African Descent; MD: Mixed Descent.
Table 4.
Multivariable regression models evaluating the relationship between minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) and covariates by racial group.
Fig 5.
Scatterplot showing the relationship between global minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) by racial group.
The relationships did not differ among the three groups. ED: European Descent; AD: African Descent; MD: Mixed Descent.
Fig 6.
Graphs showing the sectorial age-related percentage decay (%/y) of (A) mean Bruch’s membrane opening minimum rim width (MRW) and (B) peripapillary retinal nerve fiber layer thickness (RNFLT) globally (central circle) and in 6 sectors. Mean decay in each sector is color-coded according to the scale in the legend. ED: European Descent; AD: African Descent; MD: Mixed Descent.
Table 5.
Multivariable regression model evaluating the relationship between sectorial Minimum Rim Width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT), adjusted for Bruch’s membrane opening (BMO) area, age and race.
Partial R squared estimating the relative importance of each predictor are given.