Fig 1.
Flow of participants through the FEMINA2 study.
Fig 2.
Breakdown of adverse pregnancy outcomes within the FEMINA2 study cohort.
Adverse pregnancy outcome was diagnosed on the basis of the occurrence of one or more classifier of adverse outcome: stillbirth, individualised birth weight centile (IBC)<10, five minute Apgar score<7, umbilical arterial pH<7.1 or base excess<-10, admission to neonatal intensive care unit (excluding for fetal abnormality, jaundice or sepsis) or neonatal death before discharge.
Table 1.
Comparison of women participating in the FEMINA2 trial and their pregnancy outcomes.
Fig 3.
Accuracy of fetal weight estimation within seven days of birth.
Bland-Altman plot comparing the difference between estimated fetal weight and actual birth weight (y axis) to the birth weight itself (x axis) for deliveries occurring between 0–7 days from study enrolment. This shows minimal systematic error in estimated fetal weight (grey solid line). The dotted lines show the limits of agreement.
Table 2.
Odds ratios for adverse pregnancy outcome by individual differentially distributed variables.
Fig 4.
Receiver operator characteristic curve comparison.
Demonstrating model performance in predicting adverse pregnancy outcome (APO) for the baseline and proposed models (see Table 3 for model components) in N = 258* pregnancies, of whom 52 (20.2%) experienced APO. The proposed models were superior to the baseline models (p<0.05). AUC = area under receiver operating characteristic curve. * maternal blood sample unavailable in 36 cases, amniotic fluid index measurement unavailable in 2 cases.
Table 3.
Components and comparison of proposed predictive models.
Table 4.
Test performance characteristics of predictive models.
Table 5.
Model performance by gestational age at presentation.