Table 1.
Characteristics of 48 index tuberculosis cases and their 230 household contacts according to the number of colony-forming units of M. tuberculosis in cough-generated aerosols and sputum acid-fast bacilli smear microscopy results.
Fig 1.
TST and IGRA results in 230 household contacts of TB patient according to the number of CFU of M. tuberculosis in cough-generated aerosols or AFB smear microscopy in the index TB case.
(A) Histograms represent the proportion of contacts with a TST ≥10mm at baseline (black) and those with TST conversion (grey). The solid line represents the median TST diameter (mm) for contacts with TST ≥10mm at baseline (circles) and maximum TST for those with TST conversion (triangles) for each exposure group. (B) Standard box plots of maximum IGRA readouts in contacts of smear + culture + TB cases. P = 0.08 for aerosol CFU, p = 0.26 for AFB sputum smear (C) Standard box plots of IGRA readouts in contacts with TST conversion. P = 0.02 for aerosol CFU, p = 0.33 for AFB sputum smear.
Table 2.
Tuberculin skin test (TST) and interferon gamma release assay (IGRA) in household contacts according to the number of colony-forming units of M. tuberculosis in cough-generated aerosols and sputum acid-fast bacilli smear microscopy results.
Fig 2.
Proportion of household contacts with a positive (≥10mm) tTST and IGRA at study completion (8–12 weeks) by contact age group and CFU of M. tuberculosis in cough-generated aerosols in the index case: Negative (CFU = 0) or positive (CFU ≥1).
The “N” under each histogram indicates the number of contacts within each age-exposure category. The stars (*) represent the median TST or mean IGRA readout associated with each group.