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Fig 1.

Flowchart of the manuscript-screening process and their inclusion in the systematic review and statistical analysis.

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Table 1.

Main characteristics of included studies.

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Table 2.

Main characteristics of included studies.

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Table 3.

Assessment of risk of bias for the clinical trials included.

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Table 4.

Assessment of risk of bias for observational study included.

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Table 5.

Evaluation of quality of evidence—GRADE approach.

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Fig 2.

Random-effects meta-analysis evaluation of the success rate of restorative treatments in outer half of dentin on occlusal surface—Experimental treatment (sealing) vs. Control treatment (Conventional restorative treatment with resin composite).

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Fig 3.

Random-effects meta-analysis evaluation of the caries arrestment of restorative treatments in outer half of dentin on occlusal surface—Experimental treatment (sealing) vs. Control treatment (Conventional restorative treatment with resin composite).

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Fig 4.

Network meta-analysis of the success rate of restorative treatments in dentin caries lesion on occlusal surface—Geometry of the network and probability ranking of the best behaviour of the treatments on occlusal surface.

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Fig 5.

Network meta-analysis of the success rate of treatments options in dentin caries lesion on occlusoproximal surface—Geometry of the network and probability ranking of the best behaviour of the treatments on occlusoproximal surface.

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Fig 6.

Network meta-analysis of the caries arrestment of different treatments options in dentin caries lesion on occlusal and smooth surfaces—Geometry of the network and probability ranking of the best behaviour of the treatments on occlusal surface and smooth surfaces.

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