Fig 1.
Examples of the extent of manual correction (refinement) of the automated segmentation necessary for adequate delineation of RNFL.
White and yellow arrows denote the places where automated segmentation underestimates and overestimates the RNFL thickness, respectively.
Fig 2.
An example of infrared fundus photography and a B-scan image obtained at baseline and methods for determination of lamina cribrosa (LC).
(a) An example of the acquired OCT image; (b) A reference line at an angle α to the horizontal line was set by connecting two points (red crosses) characterizing the Bruch’s membrane opening (BMO). Eight points describing the anterior LC surface (red dots) were manually placed using a specially designed graphic user interface; (c) An image rotated by α. The LC depth (LCD) was automatically calculated as the maximum perpendicular distance (corresponding to maximally depressed point) between the points of anterior LC surface and the BMO line.
Table 1.
Baseline data.
Fig 3.
The time course of the intraocular pressure (IOP) (A), lamina cribrosa depth (LCD) (B) and average RNFL thickness (C) at each control visit with respect to the baseline values. The error bars denote one standard error. Note that the points on the abscissa are not equidistant.
Table 2.
The rate (speed) of retinal nerve fiber layer thinning over time.
The units are μm per year. Positive values correspond to thickening while negative values correspond to thinning.
Table 3.
Results of univariate and multivariate linear regression analyses to determine factors associated with the IOP reduction, change in the LCD and RNFL thickness.
Listed are only those variables that achieved univariate correlation at the significance level of ≤ 0.1.
Fig 4.
Correlations between RNFL rate at FUpv–6pv and LCD rate at FUpv (top plot) and between RNFL FUpv and LCD rate at 6pv (bottom plot).
Fig 5.
The time course of RNFL thinning with the corresponding IOP and LCD measurements for the right eye of a 62-year-old male patient.
FUpv at 20 months. G = global, TS = temporal superior, T = temporal, TI = temporal inferior, NS = nasal superior, N = nasal, NI = nasal inferior.
Fig 6.
The time course of RNFL thinning with the corresponding IOP and LCD measurements for the left eye of an 81-year-old female patient.
FUpv at 21 months. G = global, TS = temporal superior, T = temporal, TI = temporal inferior, NS = nasal superior, N = nasal, NI = nasal inferior.