Table 1.
MNI coordinates of the twelve regions-of-interests (ROIs) of the somatosensory processing network adopted to explore ROI-to-ROI resting-state functional connectivity.
Fig 1.
Fig 1 displays the lesion location of all patients. All lesions were flipped to the right site. Color indicates the lesion locations from red (not lesioned in any patient) to yellow (lesioned in most patients).
Table 2.
Patient characteristics (n = 19).
Fig 2.
Prevalence of somatosensory deficits.
Fig 2 displays the prevalence of somatosensory deficits for each subscale of the Em-NSA, Two-poindiscrimination test and Peceptual Threshold of Touch. Em-NSA: Erasmus MC modified (revised) Nottingham sensory assessment; NSA: Nottingham sensory assessment (gray scale, 1.5 colllum).
Fig 3.
Group differences in somatosensory network connectivity between patients with severe and mild to moderate somatosensory impairment.
Fig 3 shows the differences in functional connectivity between subgroups, investigated by a general linear model with the index of network connectivity as dependent variable; ‘group’ (severe, mild to moderate) as between-subject factor, and age, centre (stroke unit where data were collected) and mean framewise displacement (FD) as covariates of no interest (nuisance regressors). Patients with severe somatosensory impairments (Em-NSA <13/32) displayed significantly lower network intrinsic connectivity in the ipsilesional intrahemispheric and interhemispheric network compared to patients with mild to moderate somatosensory impairments (Em-NSA ≥13/32). Networks are displayed in frontal plane in back view; Error bars display the Standard Error of mean; *p< 0.05; ** p<0.01; ***p<0.001 (gray scale, 2-collum fitting).
Fig 4.
Brain-behaviour associations between specific somatosensory modalities.
Correlation plots between behavioural assessment and residuals of the partial correlations with the index inter- or intrahemispheric functional connectivity. Correlation plot between the perceptual threshold of touch and ipsilesional intrahemispheric network (A) and interhemispheric network (B); correlation plot between interhemispheric network and light touch (C) and stereognosis (D). (gray scale; 2-collum fitting).
Table 3.
Partial correlations (non-parametric) between network indices and somatosensory modalities.