Table 1.
Permeability data from static diffusion cell experiments using pig skin.
Fig 1.
Ratios between apparent permeability coefficients (Kp) for neat solvent obtained in the present study and those previously reported plotted over the log octanol:Water partition coefficient (log P estimated using US EPA [73]).
Data were available for 20 chemicals, of which 9 had been tested on humans in vivo (13 ratios) and 18 on animal or human skin in vitro (47 ratios). Notes: 1: toluene, styrene and ethylbenzene [37–39]; 2: cyclohexanone [46]; 3: ethanol and methanol [55,62]; 4: ethylbenzene, n-hexane, toluene [52, 54].
Fig 2.
Lag time (min) plotted over molecular weight (g/mol).
Fig 3.
Steady state flux (mg cm-2 h-1) plotted in log scale over number of carbon atoms in the molecule.
Fig 4.
Ratio of apparent permeability coefficient (dilute / neat, log scale) plotted over the log octanol: Water partition coefficient (log P, estimated using US EPA[73]).
Fig 5.
Predicted (EPISuite, US EPA [73]) versus experimental (present study) permeability coefficients (Kp, cm/h) for neat (n = 36) and water diluted organic solvents (n = 31).
Note the log scale on both axes, S1 Fig shows the data on linear scale.