Fig 1.
Study design.
Fig 2.
Modified scale of Gurney et al. [20] used to score sedation in 12 healthy Beagles every 5 minutes from 5 minutes after IM injection of 4 mg kg-1 alfaxalone until they were standing.
Fig 3.
Median sedation scores and corresponding mean alfaxalone plasma concentration assessed every five minutes after IM administration of 4 mg kg-1 of alfaxalone in 11 healthy Beagles.
Table 1.
Mean (± SD) cardiorespiratory variables, alfaxalone plasma concentration, and median (range) sedation scores following 4 mg kg-1 alfaxalone administered intramuscularly in healthy Beagles during sedation alone (week I) and during echocardiography under sedation (week II).
Fig 4.
Boxplot of the log of the plasma concentration of alfaxalone at different time-points after application.
Note the nearly linear relationship from T+10 onwards. T+0: alfaxalone administration; T+5, T+10, T+15, T+25, T+35, and T+50: 5, 10, 15, 25, 35, and 50 minutes after alfaxalone administration.
Table 2.
Mean (± SD) arterial blood gas analysis following 4 mg kg-1 alfaxalone administered intramuscularly in 11 healthy Beagles.
Table 3.
Mean (± SD) echocardiographic measurements in 12 healthy conscious and alfaxalone-administered (4 mg kg-1 intramuscularly) Beagles.