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Fig 1.

PRISMA flow diagram of study selection.

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Fig 2.

Overview of study characteristics.

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Table 1.

Cost-effectiveness finding of KRAS testing for corresponding targeted therapies.

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Table 1 Expand

Table 2.

Cost-effectiveness finding of RAS testing for corresponding targeted therapies.

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Table 2 Expand

Table 3.

Cost-effectiveness of UGT1A1 testing.

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Table 3 Expand

Table 4.

Cost-effectiveness of targeted therapies licensed with companion biomarkers.

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Table 4 Expand