Table 1.
QUADAS-2 framework for quality assessment.
Fig 1.
Flow diagram of inclusion and exclusion of studies. Reasons for exclusion are: conference proceedings and abstracts only; language (not English or French); technique (imaging-based, culture-based, commercial IGRA); reviews (narrative review, systematic review, meta-analysis); or target of paper (epidemiological, molecular biology, cost effectiveness, vaccine or drug study; biomarkers for detection of LTBI, prediction of disease progression or treatment monitoring). Studies that only included adult patients were also excluded.
Table 2.
Study characteristics with measures of biomarker accuracy.
Fig 2.
Quality assessment of childhood TB biomarker studies.
Results from assessment of the quality of each study in the systematic review using QUADAS-2 framework.