Table 1.
Commonly observed ASD-related DEGs in this and previous studies.
Fig 1.
Effects of VPA on zebrafish survival, hatching status, and development.
NA: not available due to significantly decreased hatching rate. The results are shown as the mean ± standard deviation (N = 4). Asterisk (*) denotes statistical significance (p < 0.05).
Fig 2.
Total distance moved (a) and active duration ratio (b) after 120 h VPA exposure. The error bars are marked separately for the dark and light phases. The analysis the total distance moved was determined for the sum of the distance moved during the dark and light phases. The results are shown as the mean ± SEM (N = 8, except control (N = 7)). Asterisks (*) indicate statistical significance (p < 0.05).
Fig 3.
Commonality of (a) DEGs and (b) GOs in the present study with respect to previous studies. (a) Data from Voineagu et al. (2011), Pinto et al. (2014), Sanders et al. (2015), Bourgeron et al. (2015), and Chang et al. (2015). (b) Data from Chang et al. (2015) and Jasien et al. (2014).
Fig 4.
Gene transcription confirmation by using qRT-PCR analysis.
The results are shown as the mean ± SEM (N = 4). Asterisks (*) and arrows indicate significant differences from the control and significant trend of the slope, respectively (p < 0.05).
Table 2.
Commonly observed GO enrichments in this and previous studies.
Table 3.
GOs that exhibited significant concentration-dependent alterations among the ASD-related GOs suggested by previous studies.