Fig 1.
Kaplan-Meier curves depicting survival profiles for rats pre-treated with (A) 1 mL/kg or (B) 3 mL/kg of Intralipid 20% ((IL) or ClinOleic 20% (CL) followed by administration of propranolol (15 mg/kg).
Fig 2.
Profiles and summarized values showing (A, B) mean arterial pressure (MAP) and (C, D) heart rate (HR) during 15 minutes of baseline (BL) stabilization following instrumentation, followed by a 60 minute period following propranolol (PR) administration.
Only hemodynamic profiles of rats surviving 120 minutes are included for Intralipid 20% (IL) (n = 18/21) and ClinOleic 20% (CL) (n = 4/20) groups; however, all normal saline (NS)-treated rats are shown (none of which survived more than 10 minutes) for reference.
Table 1.
Time to recovery to 50%, 75%, and 90% of baseline mean arterial pressure values in resuscitated survivors given 1, 2, or 3 mL/kg intravenous lipid emulsion.
Fig 3.
Kaplan-Meier curves depicting survival profiles following propranolol (15 mg/kg) overdose and subsequent treatment with (A) low-dose (1, 2, or 3 mL/kg) Intralipid 20%(IL) and (B) low-dose (1, 2, or 3 mL/kg) ClinOleic 20% (CL).
Fig 4.
(A) Combined Kaplan-Meier curves depicting survival profiles following propranolol (15 mg/kg) overdose and subsequent treatment with low-dose (1, 2, or 3 mL/kg) Intralipid 20% (IL), low-dose (1, 2, or 3 mL/kg) ClinOleic 20% (CL) and 1 mL/kg normal saline (NS). (B) Median survival times of rats depicted in (A). **P<0.01, ***P<0.0001, n.s. not significant.