Fig 1.
Flow chart of study procedures.
From eligible 4,320 cycles with the initial criteria of fresh ET, 480 cycles met the Bologna criteria of POR. Finally, 156 cycles were selected after screening with exclusion criteria. At every follow-up visit, regular evaluations and assessments were made in both groups.Totally, 156 cycles with POR received fresh ET using LPS consisting of three doses of hCG (1500IU) plus Crinone 90 mg qd beginning 2 days after OPU were included in this study. One hundred cycles were in the study group with early stop of progesterone and 56 were in the control group without early stop. There were no statistically significant differences observed in baseline characteristics between two groups, as age (39.5 ± 3.8 vs. 39.9 ± 3.1 year; P = 0.51), body mass index (BMI) (21.8 ± 2.5 vs. 22.3 ± 2.8 kg/m2; P = 0.34), causes of infertility (P = 0.91), gravida (0.91 ± 1.1.5 vs. 0.96 ± 0.94; P = 0.77), parity (0.25 ± 0.55 vs. 0.16 ± 0.41; P = 0.26), previous artificial abortion (0.14 ± 0.37 vs. 0.21 ± 0.49; P = 0.33), spontaneous abortion (0.48 ± 0.79 vs. 0.52 ± 0.71; P = 0.77) and ectopic pregnancy (0.05 ± 0.26 vs. 0.04 ± 0.19; P = 0.69). The general demographics of the patient cohort are listed below (Table 1).
Table 1.
Demographics of patients.
Table 2.
IVF characteristics of the two groups with early stop of progesterone or continuation.
Table 3.
Pregnancy outcomes for the early stop of progesterone supplement and control groups.
Table 4.
Overall reproductive outcomes in multivariate analysis.