Table 1.
Univariate analysis of 122 patients with EGFR exon19 mutation.
Fig 1.
Three mutation subtypes of EGFR exon19.
The mutation pattern of group CD(codon deletion), with a deletion of one or more original codons(A); The mutation pattern of group CSS(codon substitution and skipping), with a deletion of one or two nucleotides but the residues could be translated into a new amino acid without changing following amino acid sequence(B); The mutation pattern of group CD/CSS+SNV(codon deletion or codon substitution and skipping plus SNV), exclude CD or CSS, there’s another SNV nearby the deletion region(C).
Table 2.
Mutation subtypes of 122 EGFR exon19 mutation.
Table 3.
Clinical characteristics of three groups.
Table 4.
The number of missing bases and amino acids of three groups.
Fig 2.
Kaplan-Meier curves of progression-free survival (PFS).
Survival curves showing that there was no significant difference in PFS between group CD and CSS(A), between group CD and CD/CSS+SNV(B). Survival curves showing significant differences were found in PFS between group CSS and CD/CSS+SNV(C). CD, codon deletion; CSS, codon substitution and skipping; CD/CSS+SNV, CD or CSS plus SNV.