Fig 1.
Flowchart of subject selection in this study.
A total of 203 outpatients undergoing HD or HDF were examined, and 154 patients were analyzed after exclusion of subjects according to criteria as shown. HD: hemodialysis, HDF: hemodiafiltration, PD: peritoneal dialysis, Hb: hemoglobin, ID: iron deficiency, TSAT: transferrin saturation.
Fig 2.
Odds ratios and forest plot for severity of symptoms in ID patients (vs non-ID).
Multivariate ORs and 95% CIs were calculated using logistic regression analysis with adjustment for age, gender, duration of dialysis, presence or absence of diabetes, dose of iron, dose of erythropoiesis-stimulating agents, serum albumin level and serum β2 microglobulin level. a: Iron sufficient patients with severe symptoms were not found, and odds ratios were calculated by adding 0.5 to each value. *: P value <0.05 for multivariate adjusted analysis. TSAT: transferrin saturation, VA: vascular access.
Fig 3.
Odds ratios and forest plot for severity of symptoms in patients with low TSAT (vs high TSAT).
Multivariate ORs and 95% CIs were calculated using logistic regression analysis with adjustment for age, gender, duration of dialysis, presence or absence of diabetes, dose of iron, dose of erythropoiesis-stimulating agents, serum albumin level, serum β2 microglobulin level and serum ferritin level. *: P value <0.05, **: P value <0.01 for multivariate analysis. TSAT: transferrin saturation, VA: vascular access.
Fig 4.
Odds ratios and forest plot for severity of symptoms in patients with low ferritin (vs high ferritin).
Multivariate ORs and 95% CIs were calculated using logistic regression analysis with adjustment for age, gender, duration of dialysis, presence or absence of diabetes, dose of iron, dose of erythropoiesis-stimulating agents, serum albumin level, serum β2 microglobulin level and serum TSAT level. *: P value <0.05 for multivariate analysis. TSAT: transferrin saturation, VA: vascular access.
Table 1.
Baseline characteristics of non-ID and ID groups.
Table 2.
Baseline characteristics of high TSAT and low TSAT groups.
Fig 5.
Relationship between TSAT and total score.
The strength of linear association between TSAT and total symptom questionnaire score was analyzed by Spearman’s correlation coefficient. TSAT: transferrin saturation.
Table 3.
Baseline characteristics of high ferritin and low ferritin groups.