Fig 1.
CABG = coronary artery bypass grafting; AVR = aortic valve replacement; AAR = ascending aorta replacement; HCA = hypothermic circulatory arrest. n indicates number of patients.
Table 1.
Patient demographics, procedural data and outcomes.
Fig 2.
Fibrinogen concentration at the sampling points and changes in relation to time point Protamine.
Clauss fibrinogen concentration in all patients during the observation period (upper graph), and relative post-CPB change as percent difference from levels at time point Protamine (lower graph). In the upper graph the light grey shaded area indicates the period of surgery. Time on CPB is shaded dark grey. The red horizontal line indicates Clauss fibrinogen at 1.5 g/L. Note that true time intervals increase between sequence points T1 and T24.
Fig 3.
Clauss fibrinogen increase after weaning from CPB, according to surgery type.
Clauss fibrinogen measurements over time, starting at the time point Protomine. The comprehensive plots show all patients, with the three types of surgery represented by different symbols. Predictions based on the fixed effects of the three respective linear mixed-effects models are superimposed.
Table 2.
Patient- and CPB-related factors influencing clauss fibrinogen levels and FIBTEM-MCF at Protamine.