Fig 1.
The workflow of obesity associated loci derived from GWAS.
Data were obtained from the NCBI Association Results Browser (http://www.ncbi.nlm.nih.gov/projects/gapplusprev/sgap_plus.htm) and HuGE Navigator (http://64.29.163.162:8080/HuGENavigator/startPagePhenoPedia.do) and analyzed by many tools.
Table 1.
SNPs located in the binding sites of obesity related transcription factors.
Table 2.
The target genes of the miRNAs reported to relate with adipogenesis and lipid metabolism.
Table 3.
Effect of obesity lead SNPs and proxy SNPs on protein phosphorylation.
Fig 2.
Protein-protein interaction network of obesity GWAS associated genes.
The nodes and edges represent the proteins (genes) and their interactions, respectively. Colored nodes represent query proteins and first shell of interactors, white nodes represent second shell of interactors, empty nodes represent proteins of unknown 3D structure, filled nodes represent some 3D structure is known or predicted. Purple edges (experimentally determined) and light blue edges (from curated databases) represent known interactions, green edges (gene neighborhood), red edges (gene fusions) and dark blue edges (gene co-occurrence) represent predicted interactions, yellow-green edges (textmining), black edges (co-expression) and light blue edges (protein homology) represent others.