Table 1.
Comparison of urodynamic parameters between conscious sham-operated and obstructed rats.
Fig 1.
Changes in the detrusor muscle thickness after pBOO and its relief for 1 wk and 3 wks based on tempol treatment.
Representative microscophs of a thin section of the bladder wall (magnification 100×). Bar graphs show the quantitative image analysis. Results are expressed as mean ± standard error of the mean. (A) untreated for 1 week; (B) tempol-treated for 1 week; (C) untreated for 3 weeks; (D) tempol-treated for 3 weeks; (E) sham; *P<0.05 versus sham; †P<0.05 versus untreated group in the same period (Mann-Whitney U test).
Fig 2.
Representative microscophs show collagen with blue staining and the muscle with purple staining (magnification 20×). Bar graphs show the quantitative image analysis. Results are expressed as mean ± standard error of the mean. (A) untreated for 1 week; (B) tempol-treated for 1 week; (C) untreated for 3 weeks; (D) tempol-treated for 3 wks; (E) sham; *P<0.05 versus sham; †P<0.05 versus untreated group in the same period (Mann-Whitney U test).
Fig 3.
Representative microscophs show TUNEL-positive cells as black-brown cells mainly localized in the bladder urothelium (magnification 400×). Bar graphs show the quantitative image analysis. The apoptotic index represents the percentage of apoptotic cells within the total number of cells in a given area. Results are expressed as mean ± standard error of the mean. (A) untreated for 1 week; (B) tempol-treated for 1 week; (C) untreated for 3 weeks; (D) tempol-treated for 3 weeks; (E) sham; *P<0.05 versus sham; †P<0.05 versus untreated group in the same period (Mann-Whitney U test).
Fig 4.
Representative Western blot shows expression of beta-3 receptor protein in the bladder, respectively. Bar graphs show the quantitative analysis for beta-3 receptor protein expression. Data are expressed as folds of corresponding expression in sham-operated rats. Results are expressed as mean ± standard error of the mean. *P<0.05 versus sham; †P<0.05 versus untreated group in the same period (Mann-Whitney U test).