Fig 1.
Literature retrieval flow chart.
Searches of PubMed, the Cochrane Library, Embase, Wanfang database and CNKI returned 264, 11, 328, 98, and 99 articles, respectively.
Table 1.
Characteristics of the included studies.
Fig 2.
Methodological quality graphs (risk of bias and applicability concerns) as percentages across the included studies.
a: composite reference standard. b: culture reference standard.
Fig 3.
Forest plot of LAMP sensitivity and specificity for tuberculosis detection in EPTB.
a: composite reference standard. b: culture reference standard. The squares represent the sensitivity and specificity of a study, and the black line their confidence intervals. The diamonds represent the pooled sensitivity and specificity and their confidence intervals. LAMP: loop-mediated isothermal amplification; EPTB: extrapulmonary tuberculosis.
Fig 4.
Forest plot of LAMP sensitivity and specificity for tuberculosis detection using different target genes against a composite reference standard.
a: MPB64. b: IS6110. The squares represent the sensitivity and specificity of one study, and the black line their confidence intervals. The diamonds represent the pooled sensitivity and specificity and their confidence intervals. LAMP: loop-mediated isothermal amplification.
Fig 5.
Forest plot of LAMP sensitivity and specificity using cerebrospinal fluid samples against a composite reference standard.
The squares represent the sensitivity and specificity of one study, and the black line their confidence intervals. The diamonds represent the pooled sensitivity and specificity and their confidence intervals. LAMP: loop-mediated isothermal amplification.