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Table 1.

Categories for the assessment of adverse events related to DBS surgery and implanted hardware.

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Table 1 Expand

Table 2.

Evaluation of study quality based on questions from common check lists.

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Table 3.

Evaluation of publication bias.

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Fig 1.

Intracerebral hemorrhages in the striatum along implanted electrodes (arrows) as detected in CT scans obtained on postoperative day three (A and B, patient#1; STN stimulation; diameter 1.2 cm) and day one (C and D, patient#2; GPI stimulation; diameter < 1 cm).

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Table 4.

Systematic review of the literature based on a triad of categories.

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Table 5.

Summary of literature-based rates for adverse events related to DBS surgery and implanted hardware.

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Fig 2.

Percent intracranial AEs per patient.

The rate of AEs is color-coded. The number of patients that have been included in respective studies are indicated by the height of the wedges (cutoff value 500 patients).

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Fig 3.

Percent hardware removal per patient.

The rate of AEs is color-coded. The number of patients that have been included in respective studies are indicated by the height of the wedges (cutoff value 500 patients).

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Fig 3 Expand

Fig 4.

Percent hardware removal per patient-year.

The rate of AEs is color-coded. The number of patient-years calculated for individual studies is indicated by the height of the wedges (cutoff value 1000 patient-years).

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Fig 4 Expand

Fig 5.

Percent lead revision per patient.

The rate of AEs is color-coded. The number of patients that have been included in respective studies are indicated by the height of the wedges (cutoff value 500 patients).

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Fig 5 Expand

Fig 6.

Percent lead revision per patient-year.

The rate of AEs is color-coded. The number of patient-years calculated for individual studies is indicated by the height of the wedges (cutoff value 1000 patient-years).

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Fig 6 Expand

Table 6.

AE rates dependent on quality of AE reporting.

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Table 6 Expand