Fig 1.
Representative optical coherence tomography (OCT) horizontal scan section of the macula of a normal (A and B) and early glaucomatous (C and D) left eye. Macular ganglion cell layer (mGCL) is marked with two asterisks, and retinal nerve fiber (mRNFL) layer is marked with one asterisk, in Fig 1B (normal eye) and 1D (glaucomatous eye). The automated segmentation performed by the OCT Spectralis software between mRNFL and mGCL is shown with a light blue line, and between mGCL and inner plexiform layer is shown with a purple line. We can appreciate a slight thinning of mGCL in the glaucomatous eye, especially temporal to fovea. Optic nerve head (ONH) position and fovea (Fo) are indicated. The infrared image obtained with the Horizontal Posterior Pole protocol of Spectralis OCT is shown in the corner of each B-scan. The green lines of the infrared image delimit the square scanning area at the posterior pole.
Fig 2.
Representative optical coherence tomography (OCT) vertical scan section of the macula of a normal (A and B) and early glaucomatous (C and D) left eye. Macular ganglion cell layer (mGCL) is marked with two asterisks, and retinal nerve fiber (mRNFL) layer is marked with one asterisk, in Fig 1B (healthy eye) and 1D (glaucomatous eye). The automated segmentation performed by the OCT Spectralis software between mRNFL and mGCL is shown with a light blue line; and the one between mGCL and inner plexiform layer is shown with a purple line. The arrow indicates superior zone, and fovea position (Fo) is also pointed out. We can appreciate a slight thinning of mRNFL in the glaucomatous eye, especially inferiorly to the fovea. The infrared image obtained with the Vertical Posterior Pole protocol of Spectralis OCT is shown in the lower left corner of each B-scan. The green lines of the infrared image delimit the square scanning area at the posterior pole.
Fig 3.
Early treatment diabetic retinopathy study (ETDRS) subfields.
Macular ganglion cell (mGCL) and retinal nerve fiber (mRNFL) layers were measured in each of the nine macular areas defined by the ETDRS circle. Abbreviation: C0, central fovea; IS, inner superior; IN, inner nasal; II, inner inferior; IT, inner temporal; OS, outer superior; ON, outer nasal; OI, outer inferior; and OT, outer temporal; RE, right eye; LE, left eye.
Table 1.
Descriptive and clinical data and mean and standard deviation of peripapillary retinal nerve fiber layer thickness, for 40 early open-angle glaucoma eyes and 43 healthy control eyes, and comparison between groups.
Table 2.
Mean and standard deviation of macular ganglion cell layer thickness obtained with horizontal and vertical scans in the control group and early glaucoma patients, and comparison between groups.
Table 3.
Mean and standard deviation of macular retinal nerve fiber layer thickness obtained with horizontal and vertical scans in the control group and early glaucoma patients, and comparison between groups.
Fig 4.
Receiver operating characteristic (ROC) curves for the macular (A) and peripapillary (B) parameters with the greater discriminating ability. Abbreviations: mRNFL, macular retinal nerve fiber layer; mGCL, macular ganglion cell layer; pRNFL, peripapillary retinal nerve fiber layer.
Table 4.
Area under the receiver operating characteristics curve (AUC) of the most relevant parameters on each layer.