Fig 1.
Phylogenetic tree of the 64 Bulgarian HEV sequences.
A red circle marks Bulgarian sequences; for each sequence, the town/village (Dup: Dupnica; Jam: Jambol; Iht: Ihtiman; Karl: Karlovo; Paz: Pazardzhik; Plev: Pleven; Plov: Plovdiv; Sam: Samokov; Sof: Sofia; Var: Varna) and the isolation year (2013, 2014, 2015) are reported after the sequence ID. Reference strains with known genotype (1, 2, 3 and 4) were included in the analysis and are marked as shown in the box. For each reference sequence, genotype/subtype (e.g. 3e), Accession number, host (hu: human; sw: swine), country and year of detection are reported. Significant bootstrap values (>70) are reported.
Fig 2.
Phylogenetic tree of the 63 HEV genotype 3 isolates from Bulgaria.
A red circle marks Bulgarian sequences; for each sequence, the town/village (Dup: Dupnica; Jam: Jambol; Iht: Ihtiman; Karl: Karlovo; Paz: Pazardzhik; Plev: Pleven; Plov: Plovdiv; Sam: Samokov; Sof: Sofia; Var: Varna) and the isolation year (2013, 2014, 2015) are reported after the sequence ID. Reference genotype 3 strains with known subtype were included in the analysis and are marked as shown in the box. For each reference sequence, genotype and subtype (e.g. 3e), Accession number, host (hu: human; sw: swine), country and year of detection are reported. Significant bootstrap values (>70) are reported.
Fig 3.
Geographical localization of the characterized HEV genotype 3 strains in Bulgarian towns/villages.
Cases are represented by a colour coded square, according to the box included in the figure. The Haskovo town, in which a patient infected by HEV genotype 1 was identified, is also reported.
Fig 4.
Onset date of cases, from Plovdiv and Pazardzhik, harbouring cluster A and cluster B sequences, 3e subtype.
Cases from cluster A and B (see Fig 2) are indicated according to the box included in the figure.