Table 1.
Summary of publications included in model.
Fig 1.
Meta-analysis of acellular pertussis vaccines.
This figure represents the relative risk (OR) of pertussis infection occurring at different time points after vaccination. The I2 values (i.e. Higgin’s I2) quantifies the proportion of heterogeneity and dispersion in the meta-analytic model. Panel A: Represents a Meta-analysis of the OR of pertussis infection when comparing children immunized with the primary acellular pertussis series (5-dose DTaP) compared to vaccine naïve children. These OR values in Panel A were the product of a mathematical transformation of relative (5-dose DTaP) OR values. Panel B: Represents a meta-analysis of the OR of pertussis infection when comparing children immunized with the full acellular pertussis series (5-dose DTaP and 1-dose Tdap) compared to children immunized with only the primary acellular pertussis series.
Fig 2.
Acellular pertussis vaccine effectiveness (VE) over time.
Panel A: The blue line represents the absolute VE (ie, vs a pertussis vaccine naïve population) of the 5-dose DTaP childhood series. The grey line represents the relative VE (ie, vs DTaP vaccine-primed population) of 1-dose Tdap vaccine given in early adolescence, as reported by previous researchers. Panel B: The blue line again represents the absolute VE of the primary acellular pertussis series. The red line represents the modeled absolute VE of the full acellular pertussis series (ie, 1 dose of Tdap vaccine given in early adolescence 6 years after completion of the DTaP childhood series).