Table 1.
Demographic information.
Table 2.
Injury severity, mechanism of injury and brain imaging findings for all TBI subjects.
Table 3.
Neuropsychological performance of TBI group.
Mean (sd) raw score.
Fig 1.
Modified digit symbol modalities task.
A. Level 1 or 2 of task as it appears in the scanner. Level 1 the symbol-digit pairing remains the same. Level 2, the symbol-digit pairing varies. B: Level 3 of the task where symbol-digit pairing in the key code is not in numerical order.
Table 4.
Motion detection summary.
Table 5.
FreeSurfer analysis: Mean (sd) volume ratio.
Fig 2.
Data processing pipeline for functional data.
Abbreviations: ICA: independent components analysis, dFC: dynamic functional connectivity,T1: structural MRI, MNI: montreal neurological institute, FWHM: full width half-maximum.
Fig 3.
Components from spatially constrained ICA.
Illustrates the results of ICA resulting in 44 viable components. Panels A-H reveal the spatial extent of components comprising distinct subnetworks. Panel I shows the dynamic range and low to high frequency ratio used to determine the inclusion of components for the study.
Table 6.
Global graph metrics for static analysis.
Table 7.
Dynamic connectivity network states.
Fig 4.
Test-retest reliability across runs for state frequency and transitions for both samples.
Panels A-C: show the test-retest reliability for the frequency data for states 3, 5, and 6. For both samples, the frequency for a state during run 1 was highly predictive of the frequency for that state in run 2. Panel D: provides test-retest reliability for the number of transitions between run 1 and run 2. Transitions in run1 predict transitions in run 2 only for the TBI sample.
Fig 5.
Examining the influence of the number of states (k) on state transitions between groups.
The TBI sample reliably shows reduced transitions irrespective of investigator decisions regarding k. Error bars indicate standard error. * = between group difference significant, p<0.1, ** = between group difference significant, p<0.05.
Fig 6.
Adjacency matrices for network states 1, 2, and 4.
Adjacency matrices for states 1, 2, and 4 which appeared only in the TBI sample. Abbreviations: Aud: auditory network, ECN: executive control network, DMN: default mode network, SM: sensory-motor network, SN: salience network.
Fig 7.
Adjacency matrix and connectogram highlighting the connectivities across subnetworks for state 3.
Abbreviations: Aud: auditory network, ECN: executive control network, DMN: default mode network, SM: sensory-motor network, SN: salience network.
Fig 8.
Adjacency matrix and connectogram highlighting the connectivities across subnetworks for state 5.
Abbreviations: Aud: auditory network, ECN: executive control network, DMN: default mode network, SM: sensory-motor network, SN: salience network.
Fig 9.
Adjacency matrix and connectogram highlighting the connectivities across subnetworks for state 6.
Abbreviations: Aud: auditory network, ECN: executive control network, DMN: default mode network, SM: sensory-motor network, SN: salience network.
Fig 10.
Cost probability distributions and hubs for state 3 for both samples.
Left: Cost probability distributions for state 3. Distributions based upon the cost for all nodes collapsed across runs for each group. Right: Hubs identified for each of the samples for state 3.
Fig 11.
Cost probability distributions and hubs for state 3 for both samples.
Left: Cost probability distributions for state 5. Distributions based upon the cost for all nodes collapsed across runs for each group. Right: Hubs identified for each of the samples for state 5.
Fig 12.
Cost probability distributions and hubs for state 3 for both samples.
Left: Cost probability distributions for state 6. Distributions based upon the cost for all notes collapsed across runs for each group. Right: Hubs identified for each of the samples for state 6.
Table 8.
Correlation between state 5 hubs and state 5 frequency in TBI.
Table 9.
Correlation between state 5 hubs cognition in TBI.
Table 10.
Examining network dynamics (transitions) after TBI.