Fig 1.
Flow chart of children aged 2 years or younger included in the study.
BPD, bronchopulmonary dysplasia; RSV, Respiratory syncytial virus; wGA, week of gestational age; ICD, International Statistical Classification of Diseases.
Fig 2.
Monthly incidence of RSVH of preterm infants in the first 2 years of age.
The baseline monthly incidence of RSVH was 0.79% of preterm children with BPD and 0.18% of infants without BPD. BPD, bronchopulmonary dysplasia; RSVH, Respiratory syncytial virus-associated hospitalization.
Table 1.
The comparisons of RSVH rates among each GA groups and BPD status of preterm infants in the first 2 years of age.
Fig 3.
The rate and proportion of RSVH by CA of onset categorized by GA and BPD status.
No RSVH occurred within 3 months of CA in infants born at <29 wGA without BPD. The incidence of RSVH started to increase after 3 months and peaked between 7–9 months of CA. Among preterm infants, 56.4% of RSVH occurred within first 9 months of CA, 71.4% within 12 months, and 87.9% within 18 months. BPD, bronchopulmonary dysplasia; CA, chronologic age; GA, gestational age; RSVH, Respiratory syncytial virus associated hospitalization; wGA, week of gestational age.
Fig 4.
Rate of ICU admission and MV usage of RSVH by GA and CA in first 2 years of age.
(A). Higher rate of ICU admission was associated with preterm infants with BPD within 18 months of CA and without BPD within 12 months of CA. (B). MV utilization was more frequent among preterm infants with BPD within 12 months of CA. BPD, bronchopulmonary dysplasia; CA, chronologic age; GA, gestational age; ICU, intensive care unit; MV, Mechanical Ventilation; RSVH, Respiratory syncytial virus associated hospitalization; wGA, week of gestational age. †p<0.05, ‡p<0.01, §p<0.001, and *p<0.0001 indicate comparisons between indicated groups in each category of CA.
Table 2.
The LOS of RSVH by GA and with or without BPD categorized by CA.