Fig 1.
Flow chart of patients included in the genetic association analysis for IL7RA polymorphisms.
Abbreviations: HCV, hepatitis C virus; IL7RA, gene of α-chain of the IL-7 receptor; LSM, liver stiffness measurement (LSM).
Table 1.
Clinical and epidemiological characteristics of HCV-infected patients.
Fig 2.
Pairwise linkage disequilibrium (LD) pattern for IL7RA polymorphisms.
Each diagonal represents a different SNP, with each square representing a pairwise comparison between two SNPs.
Table 2.
Summary of Hardy Weinberg Equilibrium and frequencies of alleles and genotypes for IL7RA polymorphisms in HCV-infected patients compared to Iberian populations in Spain (IBS) and Utah residents with Northern and Western European ancestry (CEU) from 1000 genomes project data (http://browser.1000genomes.org/index.html).
Fig 3.
Summary of the relationship between IL7RA polymorphisms and variation of liver stiffness measurements (LSM) and fibrosis stages in HCV-infected patients with an additive inheritance model.
Statistical: p-values were calculated by univariate and multivariable regression adjusted by the most important clinical and epidemiological characteristics (see statistical analysis section). Significant differences are shown in bold. Abbreviations: LSM, liver stiffness measure; kPa, kilopascal; LSM1, baseline LSM; LSM2, final LSM; Exp(B), arithmetic mean ratio (AMR) for continuous variable and odds ratio (OR) for categorical variables; 95%CI, 95% of confidence interval; p-value, level of significance; F≥3, advanced fibrosis; F4, cirrhosis; IL7RA, α-chain of the interleukin 7 receptor.