Fig 1.
Chemical structures of 2’-deoxy-2’-[18F]fluoro-β-D-arbiofuranosylcytosine ([18F]FAC) and its analogs.
Fig 2.
Classical synthesis of [18F]FAC employing HBr for activation and coupling to the cytosine silylether developed by Radu’s group.
Fig 3.
Synthetic scheme for the synthesis of [18F]FAC using TMSOTf assisted coupling of 1.3.5-tribenzoyl-2-deoxy-2-[18F]fluoro-arabinofuranose with cytosine silyl ether using microwave heating.
Fig 4.
a) HPLC chromatogram showing the purification of [18F]FAC using a semi preparative HPLC system. Blue line: radioactive signal from radioactive detector Red line: UV signal from UV detector @ 254 nm. b) Quality control analysis of [18F]FAC with analytical HPLC system showing coinjection of purified [18F]FAC from preparatory column and non-radioactive FAC.