Fig 1.
Diagnosis of B. burgdorferi infection by C6 Lyme ELISA.
Histogram showing the Lyme Index distribution produced by C6 Lyme ELISA conducted on all 192 patient samples. An index ≤ 0.90 is a negative Lyme diagnosis (118 samples), an index of 0.91–1.09 is an equivocal result (7 samples), and an index ≥ 1.10 is a positive Lyme diagnosis (67 samples).
Table 1.
Diagnosis of Lyme disease by qPCR and two-tier serology.
Table 2.
Diagnosis o Lyme disease by qPCR and serological tests.
Fig 2.
Venn diagram summarizing the agreement in positive diagnoses of Lyme disease using different diagnostic methods.
B. burgdorferi infection can be detected by qPCR at a higher rate than C6 Lyme ELISA and 2-tier serological tests. There is significant overlap among all three tests.
Table 3.
Detection of single and co-infections of B. burgdorferi and B. microti using qPCR.